STO-MP-HFM-223 - Biological Effects of Ionizing Radiation Exposure and Countermeasures: Current Status and Future Perspectives

Effets biologiques de l’exposition aux rayonnements ionisants et mesures de prévention : Situation actuelle et perspectives futures

STO-MP-HFM-223 AC/323(HFM-223)TP/483
ISBN 978-92-837-0179-8
NATO Science and Technology Organization
List of National Distribution Centres
Papers presented at the RTO Human Factors and Medicine Panel (HFM) Symposium held in Ljubljana, Slovenia from 8 to 10 October 2012.
October 2012
456 (excludes supporting material where applicable)
This document is distributed in accordance with NATO Security Regulations and STO policies.
Radiobiology ; Dose assessment ; Prevention and treatment of radiation injuries ; Low-level and late effects ; Psycho-social effects ; Medical countermeasures ; Dose assessment ; Biological dosimetry ; Depleted uranium ; Carcinogenesis
The worldwide use of sources of ionizing radiation for medical, industrial, research and other purposes is inextricably associated with the risk of accidental human exposure. In addition, a constant threat of a nuclear explosion or radiation release, whether during military or terrorist events or as a result of accidents in nuclear power plants keeps raising a possibility of overexposure of the military personnel, workers, and general public to ionizing radiation. As indicated by the recent events at the Fukushima power plant, ongoing terrorist activities, and intelligence information, there is a strong sentiment that it is not a Discussion of if, but when, a radiological or nuclear event materializes. The high potential for the occurrence of such events calls for action plans, guidance, and pre-positioned resources and expertise provided by the defence forces in order to assess, triage and medically manage the exposed individuals and inform commanders’ options for operating in contaminated or potentially contaminated areas. The need to research and develop new and improved methods to counter the nuclear/radiological threats is clear and unambiguous.

This Symposium will adopt a comprehensive approach and will provide a forum and a focus for the most important multi-disciplinary science and medicine, necessary to increase our understanding of ionizing radiation biological effects. Two keynote speakers will introduce sessions and themes to explore and to expose key issues and concepts.

• Mechanisms of injuries caused by higher doses of ionizing radiation and of effects of low-level exposures;

• State-of-the-art physical, chemical and biological dosimetry assays for estimation of radiation exposure and severity of radiation injuries;

• On-site medical management and hospital treatment of victims overexposed to ionizing radiation;

• New radio-protective (administered prior to exposure) and -remedial (applied post-exposure) substances and agents;

• Predictors and indicators of radiation-induced carcinogenesis

• Improvements in prevention and treatment of radiation-induced fibrosis;

• Psycho-social effects of inadvertent exposures to ionizing radiation;

• Practical recommendations based on the cutting edge of research into ionizing radiation bio-medical effects and countermeasures.

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List of Papers Presented (click to download individual paper)

Title or File Name Download
Cover Pages Available
Executive Summary and Synthèse Available
Technical Evaluation Report
Pellmar, T.
Programme Committee Available
Keynote KN1 - Balanced Approaches to NR Medical Countermeasures - Not available at the time of publishing
Meineke, V.
Not available
Keynote KN2 - Military and Civilian Shared Priorities in NR Readiness - Not available at the time of publishing
Hatchett, R.
Not available
Paper 1 - Göttingen Minipig Model of the Acute Radiation Syndrome
Moroni, M.; Whitnall, M.H.
Paper 2 - Indications of Delayed Susceptibility and Sensitivity of Late-Responding Tissues to Secondary Insult Following Radiation: Variations on A Theme of RI-MODS
Williams, J.P.; O’Banion, M.K.; Olschowka, J.; Lord, E.; Ryan, J.; Palis, J.; Calvi, L.; Finkelstein, J.N.
Paper 3 - Radio-Induced Cognitive Impairment at Sublethal Dose in a Rat Model: The GABA Hypothesis
Martigne, P.; Diserbo, M.; Fauvelle, F.; Lamproglou; I.; Amourette, C.
Paper 4 - Development of Models to Study Radiation Late Effects and Identify Mechanism-Responsive Biological Countermeasures
Miller, A.C.
Paper 5 - Overview of Biological Effects of Ionizing Radiation Combined Injury
Kiang, J.G.
Paper 6 - Effect of Low Doses of Low-Let Radiation on the Innate Anti-Tumour and Inflammatory Reactions in Mice
Nowosielska, E.M.; Cheda, A.; Wrembel-Wargocka, J.; Janiak, M.K.
Paper 7 - Cell-Based Biosensor System for Detection of Radiation-induced Genetic Damage using Red Fluorescent Protein
Cemazar, M.; Filipic, M.; Zager, V.; Blagus, T.; Bojana Zegura, B.; Hreljac, I.; Kamensek, U.; Sersa, G.
Paper 8 - Biological Dosimetry by the Micronucleus Test: A Validation Study for the Application in Radiation Mass Casualties
Bolognesi, C.; Ropolo, M.; Roggieri, P.; Bruzzi, P.
Paper 9 - Retrospective Biodosimetry by FISH Chromosome Painting Translocation in a Cohort of Italian Soldiers with Past Deployments in the Balkan Area: Preliminary Data
De Amicis, A.; Capozzi, O.; Amati, A.; Di Cristofaro, S.; Franco, M.; Regalbuto, E.; Rocchi, M.; Lista, F.; De Sanctis, S.
Paper 10 - Transcriptional Profiling of Epidermal Cells Exposed to Alpha Particle Radiation for the Development of Biological Assessment Tools
Chauhan, V.; Howland, M.; Wilkins, R.
Paper 11 - Cytogenetic Markers for Low-Doses X-Rays Exposure in Mammalian Cells, Comparison Between Two FISH Techniques
Nieri, D.; Berardinelli, F.; Antoccia, A.; Tanzarella, C.; Sgura, A.
Paper 12 - The Gamma-H2AX Assay as a High Throughput Triage Tool: Comparison of Two Prototype Devices
Rothkamm, K.; Horn, S.; Pope, I.; Barber, P.R.; Barnard, S.; Moquet, J.; Tullis, I.; Vojnovic, B.
Paper 13 - Improvement of Radiation Overexposure Expertise and Population Triage by Automatic Detection of Dicentrics
Voisin, P.; Vaurijoux, A.; Gruel, G.; Gregoire, E.; Roch-Lefevre, S.; Voisin, P.; Martin, C.; Barquinero, F.
Paper 14 - Withdrawn Not available
Paper 15 - Use of EPR Dosimetry for Field Deployable Triage for a Large Radiation Event
Swartz, H.M.; Williams, B.B.; Dong, R.; Swarts, S.G.; He, X.; Grinberg, O.; Sidabras, J.; Varanasi, S.; Flood, A.B.
Paper 16 - Assessment of Total- and Partial-Body Irradiation In a Baboon Model: Reliability of the Dicentric Assay
Valente, M.; Grenierm, N.; Mayol, J-F.; Gouard, S.; Chaussard, H.; Martigne, P.; Baugé, S.; Hérodin, F.
Paper 17 - A Multiparameter Approach to Assess Total- and Partial-Body Irradiation In a Baboon Model
Hérodin, F.; Grenier, N.; Arvers, P.; Valente, M.; Denis, J.; Mayol, J-F.; Bois, D.; Martigne, P.; Baugé, S.; Gérome, P.; Drouet, M.
Paper 18 - Perspective on Translational Biological Dosimetry Research Programs: Strategy for Military Operational Applications
Blakely, W.F.; Meineke, V.
Paper 19 - RENEB – Realising the European Network in Biological Dosimetry
Voisin, P.; Ainsbury, L.; Atkinson, M.; Barquinero, J.; Barrios, L.; Beinke, C.; Darroudi, F.; Fattibene, P.; Gil, O.; Hadjidekova, V.; Haghdoost, S.; Herranz, R.; Jaworska, A.; Lindholm, C.; Mörtl, S.; Montoro, A.; Moreno, M.; Oestreicher, U.; Palitti, F.; Pantelias, G.; Popescu, I.; Romm, H.; Rothkamm, K.; Sabatier, L.; Sommer, S.; Testa, A.; Thierens, H.; Trompier, F.; Turai, I.; Vaz, P.; Vral, A.; Woda, C.; Wojcik, A.; Kulka, U.
Paper 20 - NATO Exercise 2011: Intra- and Inter-Assay Comparison of Established and Emerging Biodosimetry Assays - Preliminary Results
Abend, M.; Rothkamm, K.; Romm, H.; Badie, C.; Balagurunathan, Y.; Barnard, S.; Bernard, N.; Boulay-Greene, H.; Brengues, M.; De Amicis, A.; De Sanctis, S.; Greither, R.; Herodin, F.; Jones, A.; Knie, T.; Kabacik, S.; Kulka, U.; Lista, F.; Martigne, P.; Missel, A.; Moquet, J.; Oestreicher, U.; Peinnequin, A.; Poyot, T.; Roessler, U.; Scherthan, H.; Terbrueggen, B.; Thierens, H.; Valente, M.; Vral, A.; Zenhausern, F.; Meineke, V.; Little, M.P.; Beinke, C.
Paper 21 - Biodosimetry Intra-Laboratory Calibration of Dicentric Chromosome Assay: Evaluation Among Three Different Scorers
De Amicis, A,; Amati, A.; Di Cristofaro, S.; Franchini, V.; Franco, M.; Regalbuto, E.; Lista, F.; De Sanctis, S.
Paper 22 - Interlaboratory Comparison on Cytokinesis-Block Micronucleus Assay for X-Ray Calibration Curve and Dose Prediction in Italy
Franco, M.; Bolognesi, C.; De Amicis, A.; Amati, A.; Di Cristofaro, S.; Regalbuto, E.; Ropolo, M.; Lista, F.; De Sanctis, S.
Paper 23 - Dose Estimation for Dicentric Chromosome Assay and Cytokinesis – Block Micronucleus Assay: Comparison Between Manual and Automated Scoring in Triage Mode
De Amicis, A.; Amati, A.; Di Cristofaro, S.; Franchini, V.; Franco, M.; Regalbuto, E.; Lista, F.; De Sanctis, S.
Paper 24 - Mitigating Radiation Adverse Effects: State of the Art and Challenges
Whitnall, M.H.
Paper 25 - Nicotynic Acid Deriveratives as New Potential Radio-Protective and Radio-Remedial Agents
Cheda, A.; Nowosielska, E.M.; Wrembel-Wargocka, J.; Gebicki, J.; Marcinek, A.; Chlopicki, S.; Janiak, M.K.
Paper 26 - Redox-Active Cerium Oxide Nanoparticles As Novel-Concept Countermeasure Against Radiation Effects?
Giovanetti, A.; Caputo, F.; Aversa, G.; Traversa, E.; Licoccia, S.; Ghibelli, L.
Paper 27 - Efficacy of a Single Early Local DTPA Treatment After Contamination with MOX (7.1% Pu) by Inhalation or Wounding in the Rat
Griffiths, N.M.; Van der Meeren, A.; Tsapis, N.; Renault, D.; Wilk, J.C.; Grémy, O.
Paper 28 - Acute Radiation Syndrome Management: Defining New Strategies to Mitigate Hematopoietic and Non Hematopoietic Toxicity
Drouet, M.; Hérodin, F.
Paper 29 - Development of CLT-008 (Novel Universal myeloid Progenitors) for Treatment of Hematopoietic Syndrome Caused Due to Exposure to Radiation
Mandalam, R.; Karsunky, H.; Tressler, R.
Paper 30 - Myeloid Progenitors Mitigate Radiation Injury and Improve Intestinal Integrity after Whole Body Irradiation
Singh, V.K.; Elliott,T.B.; Mandalam, R.; Karsunky, H.; Sedello, A.K.
Paper 31 - Adipocyte-Derived Cells are Promising Tools to Treat Cutaneous Radiation Syndrome
Forcheron, F.; Agay, D.; Riccobono, D.; Scherthan, H.; Ballester, B.; Vivier, M.; Meineke, V.; Drouet, M.
Paper 32 - An Original Personalized Regenerative Treatment Combining Both Surgery and Stem Cell Therapy to Heal Accidental Radiation Burns
Bey, E.; Duhamel, P.; Thepenier, C.; Brachet, M.; Bargues, L.; Amabile, J-C.; de Revel, T.; Benderitter, M.; Lataillade, J-J.
Paper 33 - Using Physiologically-Based Modeling Tools to Inform Operational Recommendations
Stricklin, D.; Millage, K.; Pellmar, T.; Reeves, G.; Oldson, D.; Li, A.
Paper 34 - Comparative Evaluation of Dosimetric Methods for Triage in Large-scale Radiation Events
Flood, A.B.; Nicolalde, R.J.; Williams, B.B.; Demidenko, E.; Evans, J.; Greene, M.A.; Swartz, H.M.
Paper 35 - A Decision Support Tool for Evaluating the Logistical Considerations of Biodosimetry Methods
Nicolalde, R.J.; Flood, A.B.; Watts, B.V.; Swartz, H.M.; Ma, L.E.; Toler, A.W.J.; Peterson, S.; Gougelet, R.M.
Paper 36 - Management of Medical and Psychosocial Consequences of a Radiological or Nuclear Terrorist Incident
Janiak, M.K.
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